I was a huge fan of the original game. However, this one feel horribly short of what the original created for me... There are three main things that threw me off: the music, the scaling of the screen, and the lack of power-ups.
Firstly, the music was low quality and almost painful to listen to for long periods as you play the game. All that distortion had me focusing so much on this annoying sound going through my head instead of just the game. It's sad since I can remember the music on the original being perfectly fine, or even GOOD.
The screen was way too small. WAY too small. Going back to play the original game, I feel like I have an entire world at my disposal. Here, I have a tiny, tiny window which often times becomes a problem. I have a hard time managing lots of germs, nowhere to maneuver them safely, and FAR too many of them drift off the screen. When the entire point of the level is for me to produce a lot of germs and most of them are being lost due to the screen size, it's not fun at all. In fact it drains my whole experience wholeheartedly. I feel cramped! Fixing this alone would change the game entirely for me and make it a real winner.
Lastly, there is a lack of any power-ups. You can still upgrade in between levels, yes, but during the missions on the original game there were drops of DNA money, bonus upgrades, etc., which were always fun to chase after and to randomly receive. It really helped out sometimes, added a bit of uniqueness to each level since you'd never get the same power ups on the same levels twice. I remember it also being a strategy of mine to purposefully make the level last as long as possible, just to try and find more power-ups. I miss that excitement and reward. So very simple, but you've slashed it completely.
If this game was made by the original author of the first... I almost can't believe it. This feels like a cheap remake. VERY cheap. And I can't help but feel extremely disappointed in all of it.
Sorry to say, but I hope the next game has some more heart put into it.
Another thing that wasn't huge: the spinning red blood cells looked choppy in their animations for me. It may have been just some lag on my part, but it was very annoying to be watching what could be a smooth animation jump around a bit by what looks like shoddy Flash skill.
So, this is a pretty average game. Nothing special.